DNA vaccines: Mechanisms and aspects of relevance for biosafety
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چکیده
DNA vaccines represent a new approach to protect against infectious disease, and hence may improve human and animal welfare, reduce antibiotic usage and reduce the spread of pathogens. Edible and injectable DNA vaccines hold prospects for rapid immunization against a variety of diseases that are difficult to eradicate with traditional vaccines and antibiotics. Other potential uses of DNA vaccines include treatment of cancer, autoimmune diseases and allergies. DNA vaccines have several attractive benefits: low cost, ease of production and improved quality control, heat stability, identical production processes for different vaccines, and the possibility of producing multivalent vaccines (Kwang 2000). On the other hand, there is a limited scientific understanding of the mechanisms underlying uptake, persistence and degradation of DNA vaccines following their injection into humans or animals. The main areas of uncertainty are related to the immunological impact, tissue distribution and persistence after injection and whether the DNA vaccine can leak into the environment.
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تاریخ انتشار 2008